[Autologous bone marrow transplantation].

By H. S. WINCHELL, MYRON POLLYCOVE, W. D. LOUGHMAN AND J. H. LAWRENCE R ELATIVELY selective beta irradiation of the lymphatic system in the dog has been achieved with internally administered Yttrium90 chelated with diethylene triamine penta-acetic acid ( Y90-DTPA) . Intravenous injection of Y#{176}#{176}-DTPA followed by continuous intravenous infusion of the animal’s own urine containing the excreted Y90-DTPA maintains a constant quantity of radioactivity in the body for a specified period. Lymphopenia, without concomitant depression of other circulating formed elements such as granulocytes, reticulocytes or platelets, was produced in dogs given sublethal irradiation with Y90-DTPA. Dogs lethally irradiated in the same way showed virtual absence of circulating lymphocytes and a less marked d#{128}pression of circulating granulocytes, reticulocytes, and platelets. Further studies of bone marrow antografts, in dogs lethally irradiated with Y9#{176}-DTPA, were made to determine whether or not the animal’s death was due primarily to bone marrow destruction.